1380359-84-1
Chemical Structure
PARPi-FL
Synonym(s): Olaparib-bodipy FL
- CAS No.: 1380359-84-1
- Formula:C34H32BF3N6O3
- Molecular Weight:640.46
IUPAC Name: 4-(3-(4-(3-(5,5-difluoro-7,9-dimethyl-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)propanoyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
InChIKey: IGUTVNUEFKPBGK-UHFFFAOYSA-N
SMILES: O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N]6[B+3]([F-])([N-]54)[F-])=O)=O)=C2)F)C7=C1C=CC=C7
Biological Activity: PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PARPi-FL | 99.77% | PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250. [Content Brief]
- [2]. Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23. [Content Brief]
- [3]. Susanne Kossatz, et al.Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Sci Rep. 2016; 6: 21371.
