1382354-26-8
1382354-26-8
Chemical Structure
NCO-141
- CAS No.: 1382354-26-8
- Formula:C21H19FN2O2
- Molecular Weight:350.39
InChIKey: SAULHIDXVGCWSE-UHFFFAOYSA-N
SMILES: O=C(N)C1=CC=CC=C1NC2=CC=CC(OCCC3=CC=CC(F)=C3)=C2
Biological Activity: NCO-141 is a selective SIRT2 inhibitor with an IC50 of 0.5 μM. NCO-141 induces cell apoptosis via caspase activation and mitochondrial superoxide anion production. NCO-141 induces cell autophagy by increasing LC3-II levels and autophagosome accumulation. NCO-141 is applicable to relevant research on leukemia[1].
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NCO-141 | NCO-141 is a selective SIRT2 inhibitor with an IC50 of 0.5 μM. NCO-141 induces cell apoptosis via caspase activation and mitochondrial superoxide anion production. NCO-141 induces cell autophagy by increasing LC3-II levels and autophagosome accumulation. NCO-141 is applicable to relevant research on leukemia. | |||||||||||||||||||||
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