138297-15-1
Chemical Structure
TP-9201
- CAS No.: 138297-15-1
- Formula:C45H69N17O14S2
- Molecular Weight:1136.26
IUPAC Name: 2-((3S,9S,12S,15S,18R,23R,26S,31aS)-23-acetamido-26-(2-amino-2-oxoethyl)-18-carbamoyl-3,15-bis(3-guanidinopropyl)-12-(4-methoxybenzyl)-1,4,7,10,13,16,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-v][1,2]dithia[5,8,11,14,17,20,23,26]octaazacyclononacosin-9-yl)acetic acid
InChIKey: RRPUNOOJZOAZNU-ALERXTORSA-N
SMILES: O=C1N2[C@](CCC2)([H])C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(N)=O)=O)NC(C)=O)C(N)=O)=O)CCCNC(N)=N)=O)CC3=CC=C(C=C3)OC)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O
Biological Activity: TP-9201 is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) (HY-W010918)-induced platelet aggregation in humans, baboons, and dogs (IC50 = 1-3 μM), while showing lower activity in rabbits (IC50 = 45 μM) and rats (IC50 = 20 μM). TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis[1].
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TP-9201 | TP-9201 is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) (HY-W010918)-induced platelet aggregation in humans, baboons, and dogs (IC50 = 1-3 μM), while showing lower activity in rabbits (IC50 = 45 μM) and rats (IC50 = 20 μM). TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis. | |||||||||||||||||||||
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