1383716-46-8
Chemical Structure
Vps34-IN-4
- CAS No.: 1383716-46-8
- Formula:C21H25N7O
- Molecular Weight:391.47
IUPAC Name: 1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol
InChIKey: XJTIGGCBXFIZJV-UHFFFAOYSA-N
SMILES: CC(O)(C)CNC1=NC=C(C2=NC(NC3=CC=NC=C3)=NC=C2)C(CC4CC4)=N1
Biological Activity: Vps34-IN-4 is an orally active and selective VPS34 inhibitor with an IC50 of 15 nM against human VPS34. Vps34-IN-4 binds to the ATP-binding pocket of VPS34. Vps34-IN-4 inhibits autophagy (autophagy) by blocking the degradation of autophagic substrates and increasing both lipidated and non-lipidated forms of LC3. Vps34-IN-4 induces time-dependent LC3-II accumulation in tumor tissues of tumor-bearing mice. Vps34-IN-4 can be used for research on cancers such as colon cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vps34-IN-4 | 98.79% | Vps34-IN-4 is an orally active and selective VPS34 inhibitor with an IC50 of 15 nM against human VPS34. Vps34-IN-4 binds to the ATP-binding pocket of VPS34. Vps34-IN-4 inhibits autophagy (autophagy) by blocking the degradation of autophagic substrates and increasing both lipidated and non-lipidated forms of LC3. Vps34-IN-4 induces time-dependent LC3-II accumulation in tumor tissues of tumor-bearing mice. Vps34-IN-4 can be used for research on cancers such as colon cancer. | ||||||||||||||||||||
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