138472-01-2
138472-01-2
Chemical Structure
FR 409
Synonym(s): NOR 3
- CAS No.: 138472-01-2
- Formula:C8H13N3O4
- Molecular Weight:215.21
IUPAC Name: (2E,3E)-4-ethyl-2-(hydroxyimino)-5-nitrohex-3-enamide
InChIKey: MZAGXDHQGXUDDX-AGLLBGTNSA-N
SMILES: NC(C(/C=C(CC)/C([N+]([O-])=O)C)=N/O)=O
Biological Activity: FR 409 (NOR3) is a NO donor and vasodilator. FR 409 increases the diameter of retinal arterioles. FR 409 is toxic to a variety of cells. FR 409 can be used in research on pain and retinopathy[1][2][3][4].
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FR 409 | FR 409 (NOR3) is a NO donor and vasodilator. FR 409 increases the diameter of retinal arterioles. FR 409 is toxic to a variety of cells. FR 409 can be used in research on pain and retinopathy. | |||||||||||||||||||||
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References
- [1]. Onishi T, et al. Acute spatial spread of NO-mediated potentiation during hindpaw ischaemia in mice. J Physiol. 2019 Jul;597(13):3441-3455. [Content Brief]
- [2]. Tsurukawa Y, et al. Mechanism of Action and Anti-Inflammatory Activity of Pestalotioquinol A, a Fungus-Derived Cytoprotective Compound. ACS Omega. 2025 Oct 8;10(41):49243-49251. [Content Brief]
- [3]. Mori A, et al. 4-Aminopyridine, a Voltage-Gated K+ Channel Inhibitor, Attenuates Nitric Oxide-Mediated Vasodilation of Retinal Arterioles in Rats. Biol Pharm Bull. 2020;43(7):1123-1127. [Content Brief]
- [4]. Mori A, et al. Role of Prostaglandins in Nitric Oxide-Induced Glial Cell-Mediated Vasodilation in Rat Retina. Biomolecules. 2022 Oct 1;12(10):1403. [Content Brief]
