138540-32-6
Chemical Structure
Atevirdine mesylate
Synonym(s): U 87201E mesylate
- CAS No.: 138540-32-6
- Formula:C22H29N5O5S
- Molecular Weight:475.56
IUPAC Name: (4-(3-(ethylamino)pyridin-2-yl)piperazin-1-yl)(5-methoxy-1H-indol-2-yl)methanone methanesulfonate
InChIKey: HKPKBPALSLUFFM-UHFFFAOYSA-N
SMILES: CS(=O)(O)=O.CCNC1=C(N2CCN(C(C3=CC4=C(C=CC(OC)=C4)N3)=O)CC2)N=CC=C1
Biological Activity: Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS[1].
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Atevirdine mesylate | Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS. | |||||||||||||||||||||
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