138660-96-5
138660-96-5
Chemical Structure
Sevirumab
Synonym(s): MSL-109
- CAS No.: 138660-96-5
- Formula:N/A
- Molecular Weight:(148.49 kDa)
IUPAC Name: 2-((2aR,4S,6aR,7aR,9aR,9bR,10R,12R,13S,15R,15aR)-15-hydroxy-3,3,9a,10,15a-pentamethyl-4-(((2R,3S,4R,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2,2a,3,4,5,6,8,9,9a,9b,10,11,12,13,15,15a-hexadecahydro-7H-12,14a-epoxycyclopropa[1',8a']naphtho[2',1':4,5]indeno[2,1-b]oxepin-13-yl)propan-2-yl acetate
SMILES: [Sevirumab]
Biological Activity: Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sevirumab | 99.9% | Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL. | ||||||||||||||||||||
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References
- [1]. Nokta M, et al. Human monoclonal anti-cytomegalovirus (CMV) antibody (MSL 109): enhancement of in vitro foscarnet- and ganciclovir-induced inhibition of CMV replication. Antiviral Res. 1994 May;24(1):17-26. [Content Brief]
- [2]. Fouts AE, et al. Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8209-14. [Content Brief]
