139088-45-2
Chemical Structure
RP 72540
Synonym(s): RPR101048
- CAS No.: 139088-45-2
- Formula:C28H30N4O6
- Molecular Weight:518.56
IUPAC Name: 2-(3-(3-(2-((3-methoxyphenyl)(2-(methyl(phenyl)amino)-2-oxoethyl)amino)-2-oxoethyl)ureido)phenyl)propanoic acid
InChIKey: ZDOYTKRSYALDTJ-UHFFFAOYSA-N
SMILES: O=C(N(C1=CC=CC(OC)=C1)CC(N(C)C2=CC=CC=C2)=O)CNC(NC3=CC=CC(C(C(O)=O)C)=C3)=O
Biological Activity: RP 72540 is a selective CCK-B receptor antagonist, with IC50 values of 2.4, 1.2, and 3.8 nM for CCK-B receptors in the guinea pig cerebral cortex, rat cerebral cortex, and mouse brain, respectively. RP 72540 effectively inhibits CCK-8-induced neuronal firing and dose-dependently inhibits gastric acid secretion, making it potentially valuable in studies of acid secretion. RP 72540 is an important tool for investigating the physiological functions of CCK B receptors[1].
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RP 72540 | RP 72540 is a selective CCK-B receptor antagonist, with IC50 values of 2.4, 1.2, and 3.8 nM for CCK-B receptors in the guinea pig cerebral cortex, rat cerebral cortex, and mouse brain, respectively. RP 72540 effectively inhibits CCK-8-induced neuronal firing and dose-dependently inhibits gastric acid secretion, making it potentially valuable in studies of acid secretion. RP 72540 is an important tool for investigating the physiological functions of CCK B receptors. | |||||||||||||||||||||
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