1391980-92-9
1391980-92-9
Chemical Structure
Necroptosis-IN-1
- CAS No.: 1391980-92-9
- Formula:C12H10ClN3O2
- Molecular Weight:263.68
IUPAC Name: 5-((7-chloro-1H-indol-3-yl)methyl)imidazolidine-2,4-dione
InChIKey: HAPHEBPGIQHYHN-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC2=CNC3=C2C=CC=C3Cl)N1)=O
Biological Activity: Necroptosis-IN-1, an analog of Necrostatin-1, is a potent necroptosis inhibitor. Necroptosis-IN-1 is a RIPK inhibitor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Necroptosis-IN-1 | 98.60% | Necroptosis-IN-1, an analog of Necrostatin-1, is a potent necroptosis inhibitor. Necroptosis-IN-1 is a RIPK inhibitor. | ||||||||||||||||||||
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Necrostatin-1 (inactive control) | 99.9% | Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor. | ||||||||||||||||||||
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Necrostatin 2 | 99.78% | Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. | ||||||||||||||||||||
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Necrostatin 2 racemate | 99.57% | Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect. | ||||||||||||||||||||
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Necrostatin 2 (S enantiomer) | 99.76% | Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 (HY-14622). Necrostatin 2 S enantiomer inhibits TNF-α-induced necroptosis in Jurkat T cells. Necrostatin 2 S enantiomer can be used for the research of ischemic brain injury (stroke). | ||||||||||||||||||||
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Necrostatin-1 (Standard) | 99.19% | Necrostatin-1 (Standard) is the analytical standard of Necrostatin-1. This product is intended for research and analytical applications. Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor. | ||||||||||||||||||||
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Cl-Necrostatin-1 | Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases. | |||||||||||||||||||||
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TDD | TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis. | |||||||||||||||||||||
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Cyclo(L-leucyl-L-tryptophyl) | 99.90% | Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand. | ||||||||||||||||||||
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N-Acetyl-L-tryptophanamide | 99.51% | N-Acetyl-L-tryptophanamide (NATA) is aamino acids and their derivatives. | ||||||||||||||||||||
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DL-5-Indolylmethylhydantoin | 99.67% | DL-5-Indolylmethylhydantoin can be used as a substrate for the enzymatic production of L-tryptophan in some specific bacteria. | ||||||||||||||||||||
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