1393102-59-4
Chemical Structure
HUHS2002
- CAS No.: 1393102-59-4
- Formula:C17H24O3
- Molecular Weight:276.37
IUPAC Name: (E)-4-(4-(hept-1-en-1-yl)phenoxy)butanoic acid
InChIKey: UISWKZAGZZSFDP-SOFGYWHQSA-N
SMILES: O=C(CCCOC1=CC=C(C=C1)/C=C/CCCCC)O
Biological Activity: HUHS2002 is a free fatty acid derivative with the ability to enhance α7 cholinergic receptor activity. HUHS2002 enhances whole-cell membrane currents of α7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner. The effects of HUHS2002 were blocked in the presence of the Ca2 /calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. HUHS2002 activated CaMKII in cultured rodent hippocampal neurons, and this activation was abolished by KN-93. HUHS2002 also partially inhibited the activity of protein phosphatase 1 (PP1) in a cell-free PP1 activity assay[1].
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HUHS2002 | HUHS2002 is a free fatty acid derivative with the ability to enhance α7 cholinergic receptor activity. HUHS2002 enhances whole-cell membrane currents of α7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner. The effects of HUHS2002 were blocked in the presence of the Ca2 /calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. HUHS2002 activated CaMKII in cultured rodent hippocampal neurons, and this activation was abolished by KN-93. HUHS2002 also partially inhibited the activity of protein phosphatase 1 (PP1) in a cell-free PP1 activity assay. | |||||||||||||||||||||
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