139461-37-3
139461-37-3
Chemical Structure
Nω-allyl-L-arginine
- CAS No.: 139461-37-3
- Formula:C9H18N4O2
- Molecular Weight:214.26
IUPAC Name: Nw-allyl-L-arginine
InChIKey: ZPQWZDPOLXVMOU-ZETCQYMHSA-N
SMILES: N[C@@H](CCCNC(NCC=C)=N)C(O)=O
Biological Activity: Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS). Nω-allyl-L-arginine can inactivate nNOS in a time-dependent manner. Nω-allyl-L-arginine also is a substrate, producing L-arginine, acrolein, and H2O[1][2].
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Nω-allyl-L-arginine | Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS). Nω-allyl-L-arginine can inactivate nNOS in a time-dependent manner. Nω-allyl-L-arginine also is a substrate, producing L-arginine, acrolein, and H2O. | |||||||||||||||||||||
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References
- [1]. Zhang HQ, et, al. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by Nω-Allyl-l-Arginine. J. Am. Chem. Soc. 1997, 119, 45, 10888-10902.
- [2]. Hah JM, et, al. Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorg Med Chem. 2000 Aug;8(8):1931-6. [Content Brief]
