1395051-72-5
1395051-72-5
Chemical Structure
BPR1J-340
- CAS No.: 1395051-72-5
- Formula:C29H34N8O3
- Molecular Weight:542.63
IUPAC Name: N-(5-(4-((3-(5-ethylisoxazol-3-yl)ureido)methyl)phenyl)-1H-pyrazol-3-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
InChIKey: VHFDRDHFZFLAAT-UHFFFAOYSA-N
SMILES: O=C(NC1=NNC(C2=CC=C(CNC(NC3=NOC(CC)=C3)=O)C=C2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4
Biological Activity: BPR1J-340 is a potent FLT3 inhibitor with an IC50 of ~25 nM. BPR1J-340 inhibits the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD+ acute myeloid leukemia (AML) cells. BPR1J-340 exhibits significant anti-tumor activities[1].
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BPR1J-340 | BPR1J-340 is a potent FLT3 inhibitor with an IC50 of ~25 nM. BPR1J-340 inhibits the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD+ acute myeloid leukemia (AML) cells. BPR1J-340 exhibits significant anti-tumor activities. | |||||||||||||||||||||
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