1396858-56-2
Chemical Structure
DDD01035881
- CAS No.: 1396858-56-2
- Formula:C14H14BrNO4S2
- Molecular Weight:404.30
InChIKey: MWDONLSMHPIZJI-UHFFFAOYSA-N
SMILES: O=S(NCC1(C2=C(OCC1)C=CC=C2)O)(C3=CC=C(Br)S3)=O
Biological Activity: DDD01035881 is a Plasmodium falciparum Pfs16 inhibitor, with an EC50 of 130 nM for exflagellation of male gametes of Plasmodium falciparum NF54 gametocytes. DDD01035881 stabilizes mature activated male gametocyte Pfs16, mimics the Pfs16-deficient phenotype, blocks the early formation process of male gametes before DNA replication, inhibits exflagellation, and exhibits male-specific activity with no activity against female gametes or asexual malaria parasite stages. DDD01035881 can be used in malaria-related research[1][2][3][4].
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DDD01035881 | DDD01035881 is a Plasmodium falciparum Pfs16 inhibitor, with an EC50 of 130 nM for exflagellation of male gametes of Plasmodium falciparum NF54 gametocytes. DDD01035881 stabilizes mature activated male gametocyte Pfs16, mimics the Pfs16-deficient phenotype, blocks the early formation process of male gametes before DNA replication, inhibits exflagellation, and exhibits male-specific activity with no activity against female gametes or asexual malaria parasite stages. DDD01035881 can be used in malaria-related research. | |||||||||||||||||||||
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References
- [1]. Rueda-Zubiaurre A, et al. Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes. Journal of medicinal chemistry. 2020 Mar 12;63(5):2240-2262. [Content Brief]
- [2]. Delves MJ, et al. A high throughput screen for next-generation leads targeting malaria parasite transmission. Nature communications. 2018 Sep 18;9(1):3805. [Content Brief]
- [3]. Yahiya S, et al. A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms. 2023 Feb 01;16(2):dmm049950. [Content Brief]
- [4]. Probst AS, et al. In vivo screen of Plasmodium targets for mosquito-based malaria control. Nature. 2025 Jul;643(8072):785-793. [Content Brief]
