1398496-82-6
1398496-82-6
Chemical Structure
Afizagabar
Synonym(s): S44819; Egis-13529
- CAS No.: 1398496-82-6
- Formula:C19H12FN3O2S
- Molecular Weight:365.38
IUPAC Name: 5-(4-fluorobenzo[b]thiophen-2-yl)-8-methyl-1,9-dihydro-2H-oxazolo[4',5':4,5]benzo[1,2-d][1,2]diazepin-2-one
InChIKey: WNUWGRVHGICCLS-UHFFFAOYSA-N
SMILES: O=C(N1)OC2=C1C=C3CC(C)=NN=C(C4=CC5=C(F)C=CC=C5S4)C3=C2
Biological Activity: Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Afizagabar | 98.40% | Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy. | ||||||||||||||||||||
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