1403610-23-0
Chemical Structure
JWU-A021
- CAS No.: 1403610-23-0
- Formula:C16H16ClN
- Molecular Weight:257.76
IUPAC Name: 2-chloro-10,10-dimethyl-5,6,9,10-tetrahydro-6,9-methanocyclohepta[b]indole
InChIKey: UMOMYASPGRBZGD-UHFFFAOYSA-N
SMILES: ClC1=CC2=C(NC3=C2C(C)(C4C=CC3C4)C)C=C1
Biological Activity: JWU-A021 is a GLP-1 secretagogue with an EC50 of 1.9 μM. JWU-A021 activates the TRPA1 cation channel to promote calcium ion influx and increase intracellular calcium levels in enteroendocrine cells and TRPA1-transfected cells. By activating the TRPA1 channel, JWU-A021 stimulates the secretion of GLP-1 from intestinal enteroendocrine cells and intestinal L cells. JWU-A021 is applicable to research related to type 2 diabetes[1].
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JWU-A021 | JWU-A021 is a GLP-1 secretagogue with an EC50 of 1.9 μM. JWU-A021 activates the TRPA1 cation channel to promote calcium ion influx and increase intracellular calcium levels in enteroendocrine cells and TRPA1-transfected cells. By activating the TRPA1 channel, JWU-A021 stimulates the secretion of GLP-1 from intestinal enteroendocrine cells and intestinal L cells. JWU-A021 is applicable to research related to type 2 diabetes. | |||||||||||||||||||||
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