140674-77-7
140674-77-7
Chemical Structure
Tyrphostin AG 537
- CAS No.: 140674-77-7
- Formula:C23H20N4O6
- Molecular Weight:448.43
InChIKey: ZHOKHSGWBNPFQU-GONBZBRSSA-N
SMILES: OC(C=C1/C=C(C#N)/C(NCCCNC(/C(C#N)=C/C2=CC(O)=C(C=C2)O)=O)=O)=C(C=C1)O
Biological Activity: Tyrphostin AG 537 is a dynamin I GTPase inhibitor with an IC50 of 1.7 μM. Tyrphostin AG 537 inhibits phospholipid-stimulated GTPase activity without competing for the GTP domain or PH domain of dynamin I. Tyrphostin AG 537 inhibits spermidine-induced autoactivation of pro-plasma hyaluronan-binding protein (pro-PHBP) with an IC50 of 0.018 μM. Tyrphostin AG 537 can be used in inflammation-related research[1][2].
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Tyrphostin AG 537 | Tyrphostin AG 537 is a dynamin I GTPase inhibitor with an IC50 of 1.7 μM. Tyrphostin AG 537 inhibits phospholipid-stimulated GTPase activity without competing for the GTP domain or PH domain of dynamin I. Tyrphostin AG 537 inhibits spermidine-induced autoactivation of pro-plasma hyaluronan-binding protein (pro-PHBP) with an IC50 of 0.018 μM. Tyrphostin AG 537 can be used in inflammation-related research. | |||||||||||||||||||||
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References
- [1]. Odell LR, et al. Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase. ChemMedChem. 2009 Jul;4(7):1182-8. [Content Brief]
- [2]. Yamamoto E, et al. Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor VII activating protease) autoactivation. Bioscience, biotechnology, and biochemistry. 2011;75(10):2070-2. [Content Brief]
