14107-37-0
Chemical Structure
Alphadolone
Synonym(s): Alfadolone
- CAS No.: 14107-37-0
- Formula:C21H32O4
- Molecular Weight:348.48
IUPAC Name: (3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethylhexadecahydro-11H-cyclopenta[a]phenanthren-11-one
InChIKey: XWYBFXIUISNTQG-VKMGZQQJSA-N
SMILES: C[C@]1([C@H](CC[C@]1([C@@]2(CC[C@]3(C[C@@H](CC[C@@]3([C@]24[H])C)O)[H])[H])[H])C(CO)=O)CC4=O
Biological Activity: Alphadolone (Alfadolone) is a GABAA positive allosteric modulator with antinociceptive activity. Alphadolone produces GABAA-mediated antinociception and analgesia, and can induce anesthesia, loss of righting reflex, and deep sedation. Alphadolone blocks calcium channels and downstream cascades of calcium influx, and inhibits histamine release from mast cells. Alphadolone enhances the antinociceptive effects of opioids. Alphadolone promotes Candida albicans yeast/hyphal growth, increases lipid and oxygen uptake, alters sterol composition, and enhances tolerance to polyene antifungals. Alphadolone can be used in pain-related research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Alphadolone | 98.71% | Alphadolone (Alfadolone) is a GABAA positive allosteric modulator with antinociceptive activity. Alphadolone produces GABAA-mediated antinociception and analgesia, and can induce anesthesia, loss of righting reflex, and deep sedation. Alphadolone blocks calcium channels and downstream cascades of calcium influx, and inhibits histamine release from mast cells. Alphadolone enhances the antinociceptive effects of opioids. Alphadolone promotes Candida albicans yeast/hyphal growth, increases lipid and oxygen uptake, alters sterol composition, and enhances tolerance to polyene antifungals. Alphadolone can be used in pain-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Nadeson R, et al. Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically. British journal of anaesthesia. 2001 May;86(5):704-8.
- [2]. Hartell NA, et al. Spinal effects of four injectable anaesthetics on nociceptive reflexes in rats: a comparison of electrophysiological and behavioural measurements. British journal of pharmacology. 1990 Nov;101(3):563-8.
- [3]. Suzuki T, et al. Inhibitory effects of steroidal anesthetics on histamine release from rat mast cells stimulated by concanavalin A, compound 48/80 and A23187. General pharmacology. 1988;19(3):435-40.
- [4]. Goodchild CS, et al. Prevention and reversal of morphine tolerance by the analgesic neuroactive steroid alphadolone. Pain medicine (Malden, Mass.). 2009;10(5):890-901.
