1414938-21-8
1414938-21-8
Chemical Structure
IRE1α kinase-IN-2
- CAS No.: 1414938-21-8
- Formula:C27H23F3N6O
- Molecular Weight:504.51
IUPAC Name: 1-(4-(8-amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea
InChIKey: MEJKZYOOTMLMBA-UHFFFAOYSA-N
SMILES: NC1=NC=CN2C1=C(C(C3=C4C=CC=C3)=CC=C4NC(NC5=CC(C(F)(F)F)=CC=C5)=O)N=C2C(C)C
Biological Activity: IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1].
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IRE1α kinase-IN-2 | 99.24% | IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines. | ||||||||||||||||||||
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