1415089-24-5
1415089-24-5
Chemical Structure
LY3023703
- CAS No.: 1415089-24-5
- Formula:C23H22F5N5O2
- Molecular Weight:495.45
InChIKey: BZYSILFNUIGABU-UHFFFAOYSA-N
SMILES: O=C(C1=CC(CNC(C(C)C)=O)=CN=C1C(F)F)NC2=NC(C)=C(C3=CC=C(C(F)(F)F)C=C3)N2
Biological Activity: LY3023703 is an orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor. LY3023703 inhibits the production of PGE2. LY3023703 is applicable to research related to inflammatory diseases and osteoarthritis pain[1][2].
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LY3023703 | LY3023703 is an orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor. LY3023703 inhibits the production of PGE2. LY3023703 is applicable to research related to inflammatory diseases and osteoarthritis pain. | |||||||||||||||||||||
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References
- [1]. Schiffler MA, et al. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. J Med Chem. 2016;59(1):194-205. [Content Brief]
- [2]. Norman BH, et al. Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury. J Med Chem. 2018;61(5):2041-2051. [Content Brief]
