14173-39-8
Chemical Structure
4-Chloro-L-phenylalanine
Synonym(s): L-PCPA
- CAS No.: 14173-39-8
- Formula:C9H10ClNO2
- Molecular Weight:199.64
IUPAC Name: (S)-2-amino-3-(4-chlorophenyl)propanoic acid
InChIKey: NIGWMJHCCYYCSF-QMMMGPOBSA-N
SMILES: N[C@@H](CC1=CC=C(Cl)C=C1)C(O)=O
Biological Activity: 4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
4-Chloro-L-phenylalanine | 99.96% | 4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Li Y, et al. Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease. Front Cell Neurosci. 2018;12:241. Published 2018 Aug 8. [Content Brief]
- [2]. Greig CJ, et al. Enhanced serotonin signaling increases intestinal neuroplasticity. J Surg Res. 2016;206(1):151-158. [Content Brief]
- [3]. Choi Y, et al. Biochemical characterization and synthetic application of aromatic L-amino acid decarboxylase from Bacillus atrophaeus. Appl Microbiol Biotechnol. 2021;105(7):2775-2785. [Content Brief]
