1417616-42-2
1417616-42-2
Chemical Structure
VU0448088
Synonym(s): ML253
- CAS No.: 1417616-42-2
- Formula:C16H15ClN4OS
- Molecular Weight:346.83
InChIKey: XNCQMFVABACABG-UHFFFAOYSA-N
SMILES: CC1=C(Cl)C(C)=NC2=C1C(N)=C(C(NCC3=CC=NC=C3)=O)S2
Biological Activity: VU0448088 (ML253) is a potent and cross the blood-brain barrier tricyclic muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator with EC50 values of 56, 176 nM for human and rat, respectively. VU0448088 has the potential for the research of psychotic[1][2].
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VU0448088 | 98.67% | VU0448088 (ML253) is a potent and cross the blood-brain barrier tricyclic muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator with EC50 values of 56, 176 nM for human and rat, respectively. VU0448088 has the potential for the research of psychotic. | ||||||||||||||||||||
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References
- [1]. Le U, et al. Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorg Med Chem Lett. 2013 Jan 1;23(1):346-50. [Content Brief]
