1418206-58-2
Chemical Structure
Proteasome-IN-9
- CAS No.: 1418206-58-2
- Formula:C26H47N3O5
- Molecular Weight:481.67
InChIKey: XAZZJHQEPVCAEX-RRTYAWIHSA-N
SMILES: CCCCCC(N[C@H](C(C)C)C(N[C@@H](CCCC)C(N[C@@H](CC(C)C)C([C@]1(CO1)C)=O)=O)=O)=O
Biological Activity: Proteasome-IN-9 is an inhibitor of the Proteasome β5 subunit of the Plasmodium falciparum 20S proteasome (Ki = 371.7 nM). Proteasome-IN-9 preferentially binds the Plasmodium β5 catalytic subunit by recognizing differences in binding pocket residues, exhibits antimalarial activity against asexual blood-stage Plasmodium and stage V gametocytes, and shows synergistic effects when combined with Artemisinin (HY-B0094). Proteasome-IN-9 can be used for research on malaria[1].
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Proteasome-IN-9 | Proteasome-IN-9 is an inhibitor of the Proteasome β5 subunit of the Plasmodium falciparum 20S proteasome (Ki = 371.7 nM). Proteasome-IN-9 preferentially binds the Plasmodium β5 catalytic subunit by recognizing differences in binding pocket residues, exhibits antimalarial activity against asexual blood-stage Plasmodium and stage V gametocytes, and shows synergistic effects when combined with Artemisinin (HY-B0094). Proteasome-IN-9 can be used for research on malaria. | |||||||||||||||||||||
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