1418747-15-5
Chemical Structure
AZ3976
- CAS No.: 1418747-15-5
- Formula:C15H19N5O3
- Molecular Weight:317.34
IUPAC Name: tert-butyl 3-((4-oxo-1,4-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)azetidine-1-carboxylate
InChIKey: CKUDSTVQYFRZJW-UHFFFAOYSA-N
SMILES: O=C1N=C(NC2CN(C2)C(OC(C)(C)C)=O)NC3=NC=CC=C13
Biological Activity: AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50 value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZ3976 | 98.05% | AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50 value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay. | ||||||||||||||||||||
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