1419299-81-2
1419299-81-2
Chemical Structure
Type-II-IN-1
- CAS No.: 1419299-81-2
- Formula:C29H22F3N5O2
- Molecular Weight:529.51
IUPAC Name: N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide
InChIKey: IMLLFFIWQIAPHC-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(C3=CC4=C(N(C)C3=O)N=C(NC5=CC=CC=C5)N=C4)=C2
Biological Activity: Type-II-IN-1 (Compound 3) is a type II spleen tyrosine kinase (Syk) inhibitor with an IC50 of 2.1 nM. Type-II-IN-1 can bind to the DFG-out conformation of Syk. Type-II-IN-1 can be used for the research of immunology, such as asthma[1].
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Type-II-IN-1 | Type-II-IN-1 (Compound 3) is a type II spleen tyrosine kinase (Syk) inhibitor with an IC50 of 2.1 nM. Type-II-IN-1 can bind to the DFG-out conformation of Syk. Type-II-IN-1 can be used for the research of immunology, such as asthma. | |||||||||||||||||||||
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