1422527-87-4
1422527-87-4
Chemical Structure
CYP1A1-IN-2
- CAS No.: 1422527-87-4
- Formula:C23H30N2O7S
- Molecular Weight:478.56
IUPAC Name: 3,4,5-trimethoxyphenyl 4-(2-oxo-3-pentylimidazolidin-1-yl)benzenesulfonate
InChIKey: FZZTWGWSVOXHQL-UHFFFAOYSA-N
SMILES: CCCCCN1CCN(C2=CC=C(S(=O)(OC3=CC(OC)=C(C(OC)=C3)OC)=O)C=C2)C1=O
Biological Activity: CYP1A1-IN-2 (Compound 14) is a competitive inhibitor of CYP1A1 (Ki: 1.4 μM). CYP1A1-IN-2 exhibits potent antimitotic activity and arrests cell in the G2/M phase. CYP1A1-IN-2 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells[1].
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CYP1A1-IN-2 | CYP1A1-IN-2 (Compound 14) is a competitive inhibitor of CYP1A1 (Ki: 1.4 μM). CYP1A1-IN-2 exhibits potent antimitotic activity and arrests cell in the G2/M phase. CYP1A1-IN-2 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells. | |||||||||||||||||||||
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References
- [1]. Chavez Alvarez AC, et al. Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes. J Med Chem. 2023 Feb 23;66(4):2477-2497. [Content Brief]
