1422527-88-5
1422527-88-5
Chemical Structure
Antitumor agent-87
- CAS No.: 1422527-88-5
- Formula:C22H28N2O6S
- Molecular Weight:448.53
IUPAC Name: 3,5-dimethoxyphenyl 4-(2-oxo-3-pentylimidazolidin-1-yl)benzenesulfonate
InChIKey: XXRAJTONBHBJIY-UHFFFAOYSA-N
SMILES: CCCCCN1CCN(C2=CC=C(S(=O)(OC3=CC(OC)=CC(OC)=C3)=O)C=C2)C1=O
Biological Activity: Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity[1].
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Antitumor agent-87 | Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity. | |||||||||||||||||||||
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References
- [1]. Chavez Alvarez AC, et al. Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes. J Med Chem. 2023 Feb 23;66(4):2477-2497. [Content Brief]
