1423018-61-4
Chemical Structure
TPP-IOA
- CAS No.: 1423018-61-4
- Formula:C42H56BrN2O2P
- Molecular Weight:731.78
IUPAC Name: (S,Z)-(3-((12-(1H-imidazol-1-yl)octadec-9-enoyl)oxy)propyl)triphenylphosphonium bromide
InChIKey: BGJYGJPVXVTDRG-UQXNWJTQSA-M
SMILES: CCCCCC[C@H](N1C=CN=C1)C/C=C\CCCCCCCC(OCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O.[Br-]
Biological Activity: TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice[1].
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TPP-IOA | TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice. | |||||||||||||||||||||
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