1423719-70-3
1423719-70-3
Chemical Structure
GPLGIAGQC
- CAS No.: 1423719-70-3
- Formula:C34H58N10O11S
- Molecular Weight:814.95
InChIKey: KROXJZMMKIZGDD-URPGPJOCSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles[1][2].
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GPLGIAGQC | GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles. | |||||||||||||||||||||
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References
- [1]. Wang MZ, et al. A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules. 2020 Jul 7;25(13):3096. [Content Brief]
- [2]. Liu XY, et al. A nano-innate immune system activator for cancer therapy in a 4T1 tumor-bearing mouse model. J Nanobiotechnology. 2022 Jan 29;20(1):54. [Content Brief]
