1426319-74-5
1426319-74-5
Chemical Structure
CHDI-340246
- CAS No.: 1426319-74-5
- Formula:C14H11ClN2O3
- Molecular Weight:290.70
InChIKey: UPKQDTLLVVTZQT-UHFFFAOYSA-N
SMILES: O=C(C1=NC=NC(C2=CC(Cl)=C(OC3CC3)C=C2)=C1)O
Biological Activity: CHDI-340246 is an orally active kynurenine monooxygenase (KMO) inhibitor. CHDI-340246 blocks KMO activity, alters the metabolic flux of the kynurenine pathway, inhibits the production of 3-hydroxykynurenine and quinolinic acid, elevates the levels of kynurenine and kynurenic acid, and restores electrophysiological abnormalities in transgenic mouse models of Huntington's disease. CHDI-340246 can be used in studies related to Huntington's disease[1][2][3].
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CHDI-340246 | CHDI-340246 is an orally active kynurenine monooxygenase (KMO) inhibitor. CHDI-340246 blocks KMO activity, alters the metabolic flux of the kynurenine pathway, inhibits the production of 3-hydroxykynurenine and quinolinic acid, elevates the levels of kynurenine and kynurenic acid, and restores electrophysiological abnormalities in transgenic mouse models of Huntington's disease. CHDI-340246 can be used in studies related to Huntington's disease. | |||||||||||||||||||||
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References
- [1]. Khetarpal V, et al. Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals. Xenobiotica. 2021;51(10):1155-1180. [Content Brief]
- [2]. Beaumont V, et al. The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease. Exp Neurol. 2016;282:99-118. [Content Brief]
- [3]. Toledo-Sherman LM, et al. Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem. 2015;58(3):1159-1183. [Content Brief]
