142645-19-0
Chemical Structure
(Rac)-BDA-366
- CAS No.: 142645-19-0
- Formula:C24H29N3O4
- Molecular Weight:423.50
IUPAC Name: 1-((3-(diethylamino)-2-hydroxypropyl)amino)-4-((oxiran-2-ylmethyl)amino)anthracene-9,10-dione
InChIKey: JYOOEVFJWLBLKF-UHFFFAOYSA-N
SMILES: O=C1C2=C(NCC3OC3)C=CC(NCC(O)CN(CC)CC)=C2C(C4=CC=CC=C41)=O
Biological Activity: (Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1][2].
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(Rac)-BDA-366 | (Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells. | |||||||||||||||||||||
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References
- [1]. Spinx Pharmaceuticals Corp. Preparation of bis(hydroxyalkylamino) anthraquinones as protein kinase C inhibitors. World Intellectual Property Organization, WO9207557 A1 1992-05-14
- [2]. Han B, Park D, Li R, et al. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015;27(6):852-863. [Content Brief]
