1426656-94-1
Chemical Structure
PACE4 Inhibitory peptide C23
Synonym(s): Ac-(DLeu)LLLRVK-Amba
- CAS No.: 1426656-94-1
- Formula:C51H90N14O8
- Molecular Weight:1027.35
InChIKey: UFNWIBYSOUCSGW-CNXVDZONSA-N
SMILES: O=C(C)N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC1=CC=C(C=C1)C(N)=N)=O)CCCCN)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C
Biological Activity: PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (Ki = 5 nM; IC50 = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice[1].
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PACE4 Inhibitory peptide C23 | 99.40% | PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (Ki = 5 nM; IC50 = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice. | ||||||||||||||||||||
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