1428630-86-7
1428630-86-7
Chemical Structure
ML254
- CAS No.: 1428630-86-7
- Formula:C18H15FN2O2
- Molecular Weight:310.32
IUPAC Name: 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide
InChIKey: YMYCVXPMSMNWEP-UHFFFAOYSA-N
SMILES: O=C(NC1(C)COC1)C2=NC=C(C#CC3=CC=CC(F)=C3)C=C2
Biological Activity: ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1]. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML254 | 97.05% | ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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References
- [1]. Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). J Med Chem. 2013;56(20):7976-7996. [Content Brief]
