1436695-49-6
1436695-49-6
Chemical Structure
VMAT2-IN-4
- CAS No.: 1436695-49-6
- Formula:C25H32ClF4NO4
- Molecular Weight:521.97
IUPAC Name: (R)-3-((2S,5R)-2,5-bis(4-(difluoromethoxy)phenethyl)pyrrolidin-1-yl)propane-1,2-diol hydrochloride
InChIKey: IUOHFZVLXJSQCL-SXWPHCFWSA-N
SMILES: OC[C@H](O)CN1[C@@H](CCC2=CC=C(OC(F)F)C=C2)CC[C@H]1CCC3=CC=C(OC(F)F)C=C3.[H]Cl
Biological Activity: VMAT2-IN-4 (compound 11) is a vesicular monoamine transporter-2 (VMAT2) inhibitor. VMAT2-IN-4 inhibits [3H]-DTBZ binding (Ki = 560 nM). VMAT2-IN-4 inhibits [3H]-DA (Ki = 45 nM) from entering vesicles and being taken up by cells. VMAT2-IN-4 can be used in methamphetamine addiction research[1].
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VMAT2-IN-4 | VMAT2-IN-4 (compound 11) is a vesicular monoamine transporter-2 (VMAT2) inhibitor. VMAT2-IN-4 inhibits [3H]-DTBZ binding (Ki = 560 nM). VMAT2-IN-4 inhibits [3H]-DA (Ki = 45 nM) from entering vesicles and being taken up by cells. VMAT2-IN-4 can be used in methamphetamine addiction research. | |||||||||||||||||||||
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