143797-62-0
143797-62-0
Chemical Structure
SB-200646A
- CAS No.: 143797-62-0
- Formula:C15H15ClN4O
- Molecular Weight:302.76
IUPAC Name: 1-(1-methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride
InChIKey: IGRYPUQJEDJLHC-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CN=C1)NC2=CC3=C(N(C)C=C3)C=C2.[H]Cl
Biological Activity: SB-200646A is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A is orally active and has electrophysiological and anxiolytic properties in vivo[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB-200646A | 99.14% | SB-200646A is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A is orally active and has electrophysiological and anxiolytic properties in vivo. | ||||||||||||||||||||
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SB-200646 | 98.38% | SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo. | ||||||||||||||||||||
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SB 204741 | 99.85% | SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1. | ||||||||||||||||||||
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BX430 | 99.21% | BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease. | ||||||||||||||||||||
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H-151 | 99.78% | H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease. | ||||||||||||||||||||
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BLT-4 | 98.09% | BLT-4 is a specific, reversible inhibitor of scavenger receptor, class B, type I (SR-BI). BLT-4 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. . | ||||||||||||||||||||
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WAY-353591 | WAY-353591 (compound 959) is a Casein kinase 1d inhibitor. WAY-353591 inhibits the tyrosinase enzyme activity with an IC50 value of 131μM. WAY-353591 that can be used in the research of neurodegenerative diseases. | |||||||||||||||||||||
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p38 Kinase inhibitor 4 | p38 Kinase inhibitor 4 (compound 135) is a potent p38 inhibitor. | |||||||||||||||||||||
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STING-IN-7 | 98.29% | STING-IN-7 is a potent STING inhibitor with an IC50 of 11.5 nM. STING-IN-7 can inhibit the phosphorylation of STING, IRF3, and TBK1. STING-IN-7 can be used in the research of autoimmune and inflammatory diseases. | ||||||||||||||||||||
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H-151 Alkyne | 95.08% | H-151 Alkyne (Compound H-151-AL) is a selective STING (Stimulator of interferon genes) inhibitor. H-151 Alkyne is promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases. | ||||||||||||||||||||
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Forchlorfenuron (Standard) | ≥98% | Forchlorfenuron (Standard) is the analytical standard of Forchlorfenuron. This product is intended for research and analytical applications. Forchlorfenuron is plant growth regulator and cytokinin; can be used to increase fruit size of fruits, such as kiwi fruit and grapes. | ||||||||||||||||||||
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References
- [1]. Blackburn TP, et al. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse. 2006 Jun 15;59(8):502-12. [Content Brief]
- [2]. Kennett GA, et al. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br J Pharmacol. 1994 Mar;111(3):797-802. [Content Brief]
