143797-63-1
143797-63-1
Chemical Structure
SB-200646
- CAS No.: 143797-63-1
- Formula:C15H14N4O
- Molecular Weight:266.30
IUPAC Name: 1-(1-methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea
InChIKey: OJZZJTLBYXHUSJ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CN=C1)NC2=CC3=C(N(C)C=C3)C=C2
Biological Activity: SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB-200646 | 98.38% | SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo. | ||||||||||||||||||||
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References
- [1]. Blackburn TP, et al. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse. 2006 Jun 15;59(8):502-12. [Content Brief]
- [2]. Kennett GA, et al. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br J Pharmacol. 1994 Mar;111(3):797-802. [Content Brief]
