143868-20-6
Chemical Structure
Galanin (1-13)-spantide I
- CAS No.: 143868-20-6
- Formula:C138H199N35O30
- Molecular Weight:2828.27
SMILES: O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CC%10=CNC%11=CC=CC=C%10%11)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: Galanin (1-13)-spantide I is a chimeric peptide composed of the N-terminal fragment of galanin (amino acids 1-13) and spantide, a known substance P receptor antagonist. Galanin (1-13)-spantide I has a high affinity for spinal galanin receptor (Kd=1.16 nM). Galanin (1-13)-spantide I can be used to study the effects of galanin on feeding behavior[1][2].
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Galanin (1-13)-spantide I | Galanin (1-13)-spantide I is a chimeric peptide composed of the N-terminal fragment of galanin (amino acids 1-13) and spantide, a known substance P receptor antagonist. Galanin (1-13)-spantide I has a high affinity for spinal galanin receptor (Kd=1.16 nM). Galanin (1-13)-spantide I can be used to study the effects of galanin on feeding behavior. | |||||||||||||||||||||
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References
- [1]. Crawley J N, et al. Galanin receptor antagonists M40 and C7 block galanin-induced feeding[J]. Brain research, 1993, 600(2): 268-272. [Content Brief]
- [2]. Xu X J, et al. New high affinity peptide antagonists to the spinal galanin receptor[J]. British journal of pharmacology, 1995, 116(3): 2076-2080. [Content Brief]
