1439488-21-7
1439488-21-7
Chemical Structure
A2AAR/hMAO-B-IN-1
- CAS No.: 1439488-21-7
- Formula:C18H16N2O2S
- Molecular Weight:324.40
IUPAC Name: N-(4-oxo-4H-benzo[d][1,3]thiazin-2-yl)-4-phenylbutanamide
InChIKey: QMBOZLGNPMVERZ-UHFFFAOYSA-N
SMILES: O=C1SC(NC(CCCC2=CC=CC=C2)=O)=NC3=C1C=CC=C3
Biological Activity: A2AAR/hMAO-B-IN-1 (compoudn 17) is a non-xanthine dual-target inhibitor targeting the A2A adenosine receptor (A2AAR) (IC50: 34.9 nM) andMAO-B (Ki: 39.5 nM, human). A2AAR/hMAO-B-IN-1 inhibits A2AAR-induced cAMP accumulation and exhibits competitive, reversible inhibition of MAO-B. A2AAR/hMAO-B-IN-1 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD)[1].
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A2AAR/hMAO-B-IN-1 | 99.0% | A2AAR/hMAO-B-IN-1 (compoudn 17) is a non-xanthine dual-target inhibitor targeting the A2A adenosine receptor (A2AAR) (IC50: 34.9 nM) andMAO-B (Ki: 39.5 nM, human). A2AAR/hMAO-B-IN-1 inhibits A2AAR-induced cAMP accumulation and exhibits competitive, reversible inhibition of MAO-B. A2AAR/hMAO-B-IN-1 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD). | ||||||||||||||||||||
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