1440532-33-1
1440532-33-1
Chemical Structure
TWIK-1/TREK-1-IN-3
- CAS No.: 1440532-33-1
- Formula:C19H27F3N2O2
- Molecular Weight:372.43
InChIKey: CGWZNOCWGMKTOS-KRWDZBQOSA-N
SMILES: O[C@H](COC1=CC=C(C(F)(F)F)C=C1)CN2CCC(N3CCCC3)CC2
Biological Activity: TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TWIK-1/TREK-1-IN-3 | 99.61% | TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects. | ||||||||||||||||||||
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