1443242-46-3
Chemical Structure
p38-α MAPK-IN-5
- CAS No.: 1443242-46-3
- Formula:C37H49N11O2
- Molecular Weight:679.86
IUPAC Name: 1-(3-(tert-butyl)-1'-(2-(dimethylamino)ethyl)-1'H-[1,4'-bipyrazol]-5-yl)-3-((1S,4R)-4-((3-((S)-2-methylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea
InChIKey: PPZSTJQLZOPKBO-LGXAAPQCSA-N
SMILES: O=C(N[C@H]1CC[C@H](C2=C1C=CC=C2)OC(C=C3)=CN4C3=NN=C4N5[C@H](CCCC5)C)NC6=CC(C(C)(C)C)=NN6C7=CN(N=C7)CCN(C)C
Biological Activity: p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].
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p38-α MAPK-IN-5 | p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research. | |||||||||||||||||||||
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