1443321-11-6
1443321-11-6
Chemical Structure
Divin
- CAS No.: 1443321-11-6
- Formula:C22H20N4O2
- Molecular Weight:372.42
IUPAC Name: (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)propanehydrazide
InChIKey: SOPYTFSYTUAGFR-OEAKJJBVSA-N
SMILES: O=C(N/N=C/C1=C2C=CC=CC2=CC=C1O)CCN3C4=CC=CC=C4N=C3C
Biological Activity: Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Divin | 95.65% | Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm. | ||||||||||||||||||||
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References
- [1]. Maoquan Zhou, et al. Structure-activity studies of divin: an inhibitor of bacterial cell division. ACS Med Chem Lett. 2013 Sep 12;4(9):880-885. [Content Brief]
- [2]. Ye-Jin Eun, et al. Divin: a small molecule inhibitor of bacterial divisome assembly. J Am Chem Soc. 2013 Jul 3;135(26):9768-76. [Content Brief]
- [3]. Thiago M A Santos, et al. Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis. ACS Chem Biol. 2018 Jan 19;13(1):235-246. [Content Brief]
