1443367-20-1
Chemical Structure
GPR35 agonist 6
- CAS No.: 1443367-20-1
- Formula:C18H12BrNO6
- Molecular Weight:418.20
IUPAC Name: 6-bromo-8-(4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid
InChIKey: TZKQFDIFVZAYER-UHFFFAOYSA-N
SMILES: O=C(O)C=1OC=2C(=CC(Br)=CC2C(=O)C1)NC(=O)C3=CC=C(OC)C=C3
Biological Activity: GPR35 agonist 6 is a potent and selective agonist targeting GPR35, with an EC50 of 12.1 nM against human GPR35. GPR35 agonist 6 activates the human splice variant GPR35b with comparable efficacy, showing an EC50 of 22.1 nM. GPR35 agonist 6 also exhibits weak GPR55 antagonistic activity, with an IC50 of 21.7 μM, and its agonistic activity towards GPR35 is significantly stronger than its antagonistic activity towards GPR55. GPR35 agonist 6 initiates GPR35 downstream signaling by inducing β-arrestin recruitment. GPR35 agonist 6 is used to investigate GPR35-mediated diseases, such as gastrointestinal lesions and gastric cancer[1].
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GPR35 agonist 6 | GPR35 agonist 6 is a potent and selective agonist targeting GPR35, with an EC50 of 12.1 nM against human GPR35. GPR35 agonist 6 activates the human splice variant GPR35b with comparable efficacy, showing an EC50 of 22.1 nM. GPR35 agonist 6 also exhibits weak GPR55 antagonistic activity, with an IC50 of 21.7 μM, and its agonistic activity towards GPR35 is significantly stronger than its antagonistic activity towards GPR55. GPR35 agonist 6 initiates GPR35 downstream signaling by inducing β-arrestin recruitment. GPR35 agonist 6 is used to investigate GPR35-mediated diseases, such as gastrointestinal lesions and gastric cancer. | |||||||||||||||||||||
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