1443994-46-4
1443994-46-4
Chemical Structure
Mongersen
Synonym(s): GED-0301
- CAS No.: 1443994-46-4
- Formula:N/A
- Molecular Weight:6604.00
IUPAC Name: (4-chloro-2-methyl-5-nitrophenyl)methanol
SMILES: [Mongersen]
Biological Activity: Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice[1][2].
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Mongersen | 98.57% | Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice. | ||||||||||||||||||||
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References
- [1]. Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372(12):1104-13. [Content Brief]
- [2]. Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24(6):1213-1224. [Content Brief]
