144412-18-0
144412-18-0
Chemical Structure
Ro 44-3888
- CAS No.: 144412-18-0
- Formula:C18H24N4O5
- Molecular Weight:376.41
InChIKey: BHOGTSLQMNCJHA-NSHDSACASA-N
SMILES: O=C(N1CCC(CC1)OCC(O)=O)[C@H](C)NC(C2=CC=C(C=C2)C(N)=N)=O
Biological Activity: Ro 44-3888 is an orally active and selective GP IIb-IIIa (fibrinogen receptor, integrin αIIbβ3) inhibitor with an IC50 of 1.9 nM against the human target. Ro 44-3888 blocks the binding of fibrinogen to GP IIb-IIIa and inhibits human ADP-induced platelet aggregation. Ro 44‑3888 is formed via the metabolism of the double prodrug Ro 48‑3657 (HY-10309). Ro 44-3888 is used in studies related to arterial thrombosis[1].
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Ro 44-3888 | Ro 44-3888 is an orally active and selective GP IIb-IIIa (fibrinogen receptor, integrin αIIbβ3) inhibitor with an IC50 of 1.9 nM against the human target. Ro 44-3888 blocks the binding of fibrinogen to GP IIb-IIIa and inhibits human ADP-induced platelet aggregation. Ro 44‑3888 is formed via the metabolism of the double prodrug Ro 48‑3657 (HY-10309). Ro 44-3888 is used in studies related to arterial thrombosis. | |||||||||||||||||||||
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