1445582-05-7
1445582-05-7
Chemical Structure
RAF-IN-4
- CAS No.: 1445582-05-7
- Formula:C23H18N4O2S
- Molecular Weight:414.48
IUPAC Name: N-(1H-indazol-4-yl)-6-(4-(methylsulfonyl)phenyl)quinolin-4-amine
InChIKey: OCYFPMVYKUWKCZ-UHFFFAOYSA-N
SMILES: O=S(=O)(C=1C=CC(=CC1)C2=CC=C3N=CC=C(NC=4C=CC=C5NN=CC54)C3=C2)C
Biological Activity: RAF-IN-4 (Compound 120) is a Raf Kinase inhibitor. RAF-IN-4 shows IC50 values of 134.3, 118.6 and 276.7 nM for B-Raf, B-Raf (V600E) and C-Raf. RAF-IN-4 can inhibit the proliferation of cancer cells by blocking the Raf signaling pathway. RAF-IN-4 can be used for research of cancer, such as lung cancer and breast cancer[1].
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RAF-IN-4 | RAF-IN-4 (Compound 120) is a Raf Kinase inhibitor. RAF-IN-4 shows IC50 values of 134.3, 118.6 and 276.7 nM for B-Raf, B-Raf (V600E) and C-Raf. RAF-IN-4 can inhibit the proliferation of cancer cells by blocking the Raf signaling pathway. RAF-IN-4 can be used for research of cancer, such as lung cancer and breast cancer. | |||||||||||||||||||||
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