1446352-68-6
1446352-68-6
Chemical Structure
PK7242
- CAS No.: 1446352-68-6
- Formula:C17H19FN4
- Molecular Weight:298.36
IUPAC Name: 2-(4-(4-fluorophenyl)-3-(1H-pyrrol-1-yl)-1H-pyrazol-1-yl)-N,N-dimethylethanamine
InChIKey: ZCQVHVWVDAEXBJ-UHFFFAOYSA-N
SMILES: CN(C)CCN1N=C(N2C=CC=C2)C(C3=CC=C(F)C=C3)=C1
Biological Activity: PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis.
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PK7242 | PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis. | |||||||||||||||||||||
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