144653-57-6
144653-57-6
Chemical Structure
Rofleponide 21-palmitate
- CAS No.: 144653-57-6
- Formula:C41H64F2O7
- Molecular Weight:706.94
InChIKey: IRCYEVZQEUIZIW-NEESCNQASA-N
SMILES: CCCCCCCCCCCCCCCC(OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C([C@H](C4)F)=CC(CC5)=O)C)F)([H])C[C@@]1([H])O[C@H](O2)CCC)C)=O)=O
Biological Activity: Rofleponide 21-palmitate is a lipophilic Corticosteroid prodrug. Rofleponide 21-palmitate reduces subcutaneous edema, plasma haptoglobin levels, and plasma levels of IL-6, KC, IP-10, MCP-1. Rofleponide 21-palmitate increases and prolongs mRNA-encoded protein expression in lipid nanoparticle formulations[1][2].
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Rofleponide 21-palmitate | Rofleponide 21-palmitate is a lipophilic Corticosteroid prodrug. Rofleponide 21-palmitate reduces subcutaneous edema, plasma haptoglobin levels, and plasma levels of IL-6, KC, IP-10, MCP-1. Rofleponide 21-palmitate increases and prolongs mRNA-encoded protein expression in lipid nanoparticle formulations. | |||||||||||||||||||||
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References
- [1]. Lennart Lindfors, et al. Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof. WO2017194454A1.
- [2]. Csöregh Ingeborg, et al. Crystal structure of (22R)-6α,9α-difluoro-11β,21-dihydroxy-16α,17α-propylmethylenedioxypregn-4-ene-3,20-dione · 2-propanol (4:1) solvate, C25H34O6F2 · 1/4(C3H8O). Zeitschrift Fur Kristallographie 214 (1999) 167-172.
