1448419-13-3
1448419-13-3
Chemical Structure
PDE5-IN-6c
- CAS No.: 1448419-13-3
- Formula:C23H21ClN4O2
- Molecular Weight:420.89
IUPAC Name: 2-acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile
InChIKey: YLBRHUHHQIYMSH-UHFFFAOYSA-N
SMILES: N#CC1=CC=C2N=C3CCN(CC3=C(C2=C1)NCC4=CC=C(C(Cl)=C4)OC)C(C)=O
Biological Activity: PDE5-IN-6c is a potent and selective phosphodiesterase 5A1 (PDE5A1) inhibitor with the potential to inhibit Alzheimer's disease (AD). PDE5-IN-6c exhibits an excellent in vitro IC50 (0.056 nM), demonstrating its potent inhibitory activity. PDE5-IN-6c has improved water solubility, making it a more attractive drug candidate[1].
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PDE5-IN-6c | PDE5-IN-6c is a potent and selective phosphodiesterase 5A1 (PDE5A1) inhibitor with the potential to inhibit Alzheimer's disease (AD). PDE5-IN-6c exhibits an excellent in vitro IC50 (0.056 nM), demonstrating its potent inhibitory activity. PDE5-IN-6c has improved water solubility, making it a more attractive drug candidate. | |||||||||||||||||||||
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