1448460-87-4
1448460-87-4
Chemical Structure
Azaphilone-9
Synonym(s): AZA-9
- CAS No.: 1448460-87-4
- Formula:C21H23BrO5
- Molecular Weight:435.31
IUPAC Name: 5-bromo-3-((S,1E,3E)-3,5-dimethylhepta-1,3-dien-1-yl)-7-methyl-6,8-dioxo-7,8-dihydro-6H-isochromen-7-yl acetate
InChIKey: XUOVORQURANBCB-LVUCCPRXSA-N
SMILES: O=C1C(C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Br)=O
Biological Activity: Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression[1].
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Azaphilone-9 | Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression. | |||||||||||||||||||||
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