144860-69-5
Chemical Structure
Reveromycin C
- CAS No.: 144860-69-5
- Formula:C37H54O11
- Molecular Weight:674.82
IUPAC Name: (2E,4S,5S,6E,8E)-10-((2R,3S,6S,8S,9R)-8-((1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl)-9-((3-carboxypropanoyl)oxy)-9-isopentyl-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid
InChIKey: NDQHXHWOEDTFCC-UHWSPUDNSA-N
SMILES: O=C(O[C@@]1(CCC(C)C)[C@H](/C=C/C(C)=C/C(O)=O)O[C@]2(O[C@H](C/C=C(C)/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)[C@@H](C)CC2)CC1)CCC(O)=O
Biological Activity: Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both).
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Reveromycin C | Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both). | |||||||||||||||||||||
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