144860-79-7
144860-79-7
Chemical Structure
L 689660 maleate
- CAS No.: 144860-79-7
- Formula:C15H18ClN3O4
- Molecular Weight:339.77
SMILES: ClC1=CN=CC(C2CN3CCC2CC3)=N1.O=C(/C=C\C(O)=O)O.[x]
Biological Activity: L 689660 maleate, a cholinomimetic agent, is a selective M1 and M3 muscarinic receptors agonist. L 689660 maleate is a potent M1 muscarinic receptor full agonist in the rat superior cervical ganglion (pEC50 of 7.3). L 689660 maleate is a potent M3 receptors agonist in the guinea-pig ileum myenteric plexus-longitudinal muscle or in trachea (pEC50 of 7.5 and 7.7, respectively)[1][2].
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L 689660 maleate | L 689660 maleate, a cholinomimetic agent, is a selective M1 and M3 muscarinic receptors agonist. L 689660 maleate is a potent M1 muscarinic receptor full agonist in the rat superior cervical ganglion (pEC50 of 7.3). L 689660 maleate is a potent M3 receptors agonist in the guinea-pig ileum myenteric plexus-longitudinal muscle or in trachea (pEC50 of 7.5 and 7.7, respectively). | |||||||||||||||||||||
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References
- [1]. Hargreaves RJ, et al. L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br J Pharmacol. 1992 Oct;107(2):494-501. [Content Brief]
- [2]. Aagaard P, et al. Pharmacological characterization of the novel cholinomimetic L-689,660 at cloned and native brain muscarinic receptors. J Pharmacol Exp Ther. 1993 Dec;267(3):1478-83. [Content Brief]
